Evaluation of triazole and isoxazole derivatives as potential anti-infective agents
نویسندگان
چکیده
منابع مشابه
Syntheses of Substituted 1,3,4-Oxadiazole, 1,3,4-Thiadiazole and 1,2,4-Triazole Derivatives as Potential Antimicrobial Agents
A series of 2-(4-nitro-1-imidazolylmethyl)-1,3,4-oxadiazole, 1,3,4-triazole and 3-(4-nitro-1-imidazolylmethyl)-1,2,4-triazole derivatives were synthesized and tested for their antimicrobial activity. Some of the tested compounds were active against Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Clostridium difficile, Aspergillus niger and Cryptococcus neoformans.
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Transcription factor NF-κB and relevant cytokines IL-6 and IL-8 play a pivotal role in thepathogenesis of inflammation. Sinapic acid is a natural product and was demonstrated to possessanti-inflammatory activity. In this paper, we synthesized a series of sinapic acid derivativesand evaluated their anti-inflammatory effects. The result suggested that all of the targetscompounds 7a-j inhibit NF-κ...
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Transcription factor NF-κB and relevant cytokines IL-6 and IL-8 play a pivotal role in thepathogenesis of inflammation. Sinapic acid is a natural product and was demonstrated to possessanti-inflammatory activity. In this paper, we synthesized a series of sinapic acid derivativesand evaluated their anti-inflammatory effects. The result suggested that all of the targetscompounds 7a-j inhibit NF-κ...
متن کاملAnti-inflammatory evaluation of isoxazole derivatives
A new series of isoxazole derivatives were synthesized by synthesizing various chalcone derivatives and cyclizing them to give resultant isoxazole derivatives (TPI1TPI20).. All the synthesized derivatives were characterized with FTIR and NMR spectral analysis and evaluated for their anti-inflammatory activity in vivo (carrageenan induced paw ooedema method in rats). The isoxazole derivatives TP...
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R Naresh Kumar, G Mallareddy, P Nagender, P Sambasiva Rao, Y Poornachandra, P Ranjithreddy, C Ganesh Kumar & B Narsaiah* a Fluoroorganic Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India b Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India c Academy of Scientific and Innovative Re...
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ژورنال
عنوان ژورنال: Medicinal Chemistry Research
سال: 2018
ISSN: 1054-2523,1554-8120
DOI: 10.1007/s00044-018-2146-4